Document 0130
 DOCN  M9490130
 TI    Comparative study on some systemic humoral and cellular immune markers
       in only HIV or HIV and hepatitis B infected children.
 DT    9411
 AU    Voiculescu C; Balasoiu M; Turculeanu A; Filipas L; Voiculescu M;
       Georgescu D; Faculty of Medicine Craiova, Department of Microbiology
       and; Immunology, Romania.
 SO    Rev Roum Virol. 1993 Jan-Jun;44(1-2):97-111. Unique Identifier :
       AIDSLINE MED/94318524
 AB    Three different groups of asymptomatic children, aged from 12 to 24
       months (30 subjects per each group), i.e. controls, only HIV, or
       HIV/hepatitis B virus (HBV) double infected, were studied, as concerned
       the following systemic immune parameters: immunoglobulin (IgG, IgM, IgA,
       IgD) levels; absolute numbers of blood CD+4, CD+8, CD+16 and CD+19
       cells; phytohaemagglutinin (PHA)-blast responsiveness of T lymphocytes;
       natural killer (NK) cell activity--as tested by means of cytotoxicity
       assays; per cent suppression of PHA-dependent T cell blastogenesis in
       the presence of concanavalin A (Con A) selected T suppressor (Ts) cells.
       On the other hand, in 15 ARC-shifting cases belonging to HIV, and
       HIV/HBV groups, respectively, a second serum sample was collected and
       searched comparatively with the corresponding first serum sample, as
       regarded: presence of total and anti-p24 HIV antibodies, patterns of
       Western Blot (WB), as well as amounts of free p24-HIV antigen. In
       asymptomatic double HIV/HBV infected subjects, some immune disorders
       occurred, at a more significant degree, as compared to only
       HIV-infected. Once the shift toward ARC being installed, in both
       infected groups a decrease of anti-p24 HIV antibody presence,
       disappearance of corresponding band in WB confirmation test, as well as
       presence of free p24 antigen in serum, were noticed. However, greater
       amounts of p24 antigen in HIV/HBV infected, as compared to only HIV
       infected patients, were found. Some considerations about diagnostic and
       predictive value of presented data are discussed.
 DE    Antibody Formation  Antigens, CD/BLOOD  AIDS-Related Complex/IMMUNOLOGY
       Biological Markers/BLOOD  Child, Preschool  Comparative Study  Hepatitis
       B/*IMMUNOLOGY  Hepatitis B Surface Antigens/BLOOD  Human  HIV
       Antibodies/BLOOD  HIV Infections/*IMMUNOLOGY  *HIV-1/IMMUNOLOGY
       Immunity, Cellular  Immunoglobulins/BLOOD  Infant  Killer Cells,
       Natural/IMMUNOLOGY  JOURNAL ARTICLE

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